NAD+ has become one of the most talked-about infusions in wellness medicine, and one of the most oversold. The underlying biology is genuinely fascinating. The human clinical evidence is genuinely thin. Both of those things are true at once, and any page that tells you only one of them is not being straight with you.
This page covers what NAD+ is, what a session actually involves — including the part most clinics do not mention — and what the research does and does not currently support.
Important information
NAD+ intravenous therapy is not approved by the U.S. Food and Drug Administration for the treatment, cure, mitigation, or prevention of any disease. Nothing on this page is a claim of efficacy, and no outcome is promised or implied. Individual results vary. This page is for general educational purposes and does not constitute medical advice, diagnosis, or treatment, and does not establish a doctor–patient relationship. NAD+ therapy is offered only following individual evaluation, is not appropriate for everyone, and is not a substitute for established medical care.
What NAD+ is
NAD+ — nicotinamide adenine dinucleotide — is a coenzyme present in every cell in your body. It is central to how cells convert food into usable energy, and it is a required substrate for several repair enzymes, including the sirtuins and PARPs involved in DNA repair and cellular maintenance.
NAD+ levels decline with age. That is well documented in laboratory research, and in animal models restoring NAD+ produces measurable improvements in mitochondrial function and markers associated with ageing. This is real science from serious laboratories, and it is why the topic gets the attention it does.
The open question — the one the marketing skips — is whether infusing NAD+ intravenously in humans produces meaningful clinical benefit. That has not been established, and we will come back to it.
What a session actually involves
This is the part most clinics underplay, and you should know it before you book.
NAD+ infusions are slow, and they are not comfortable. Infused too quickly, NAD+ commonly produces chest tightness, abdominal cramping, nausea, flushing and a general sense of unease. It is not dangerous, but it is unpleasant, and the only way to manage it is to slow the drip right down.
That means a full NAD+ infusion typically takes two to four hours, sometimes longer for a first session. Anyone offering you a quick NAD+ drip on a lunch break is either using a very small dose or is going to make you feel unwell.
- Evaluation first. History, current medications, and in most cases recent labs.
- Slow start. We begin at a low rate and increase only as you tolerate it.
- You tell us how you feel. The rate is adjusted throughout based on your symptoms. This is a collaborative infusion, not a set-and-forget one.
- Monitoring. Clinical staff supervise you throughout.
- Afterward. Most people feel fine and go about their day. Some feel tired.
Bring something to do. You will be there a while.
What we use it for
People come to us about NAD+ for chronic fatigue, brain fog and cognitive complaints, post-viral illness including Long COVID, recovery from prolonged stress or burnout, and general healthy-ageing interest.
Whether NAD+ is the right answer for any of those depends on what is actually driving the fatigue — and fatigue has a long list of causes worth ruling out first, including thyroid dysfunction, anaemia, sleep apnoea, mold and biotoxin illness, Epstein-Barr reactivation and depression. An expensive infusion for undiagnosed sleep apnoea helps nobody.
What the research currently shows
We want to be straightforward, because there is a great deal of confident marketing around NAD+.
The preclinical evidence is strong and genuinely interesting. NAD+ decline with age is well documented, and in animal models restoring NAD+ improves mitochondrial function, metabolic markers and several measures associated with ageing.
The human evidence is much more limited. Most clinical research to date has used oral NAD+ precursors — nicotinamide riboside and nicotinamide mononucleotide — rather than intravenous NAD+. Those trials generally show that blood NAD+ levels can be raised safely, but results on clinical outcomes such as energy, cognition and physical function have been modest and inconsistent. Trials of intravenous NAD+ specifically are few and small. One pharmacokinetic study demonstrated that IV NAD+ does reach the bloodstream and is metabolised, which tells us it gets in — not that it produces benefit.
There is a longer history of IV NAD+ use in addiction and withdrawal settings, but that too rests largely on clinical reports rather than controlled trials.
NAD+ IV therapy is not FDA-approved for the treatment of any condition. If a clinic tells you NAD+ will reverse ageing, repair your DNA, or resolve chronic fatigue, they are describing something the evidence does not currently establish. We are not going to tell you that.
What we can tell you is that we will look for the treatable causes of your fatigue first, be honest about where NAD+ sits in the evidence, tell you what a session is actually like, and be clear when we think something else would serve you better.
Practical details
We are direct-pay
Venturis Clinic does not bill insurance. NAD+ is one of the more expensive infusions offered here, largely because of how long a session takes. Cost is discussed openly before anything is scheduled.
Where we are
Venturis Clinic is at 7917 N May Ave, Suite B, Oklahoma City, OK 73120, in the Nichols Hills area of north Oklahoma City, serving the OKC metro and the wider state.
Frequently asked questions
Is there NAD+ IV therapy near me in Oklahoma City?
Venturis Clinic offers NAD+ infusions at 7917 N May Ave, Suite B, Oklahoma City, OK 73120, serving the OKC metro including Edmond, Nichols Hills, Norman and Moore. Call (405) 848-7246.
How long does an NAD+ infusion take?
Typically two to four hours, sometimes longer for a first session. NAD+ has to be infused slowly to be tolerable, and anyone promising a quick drip is either using a very low dose or has not warned you how it will feel.
Does NAD+ IV therapy feel unpleasant?
It can, if infused too quickly — chest tightness, cramping, nausea and flushing are common at higher rates. This is managed by slowing the infusion, and we adjust throughout based on how you feel.
Is NAD+ IV therapy FDA-approved?
No. NAD+ IV therapy is not approved by the FDA for the treatment of any condition.
Does it actually work?
The preclinical science is strong; the human clinical evidence, particularly for intravenous NAD+, is limited and inconsistent. We will not tell you it works. We will tell you honestly what is known and let you decide.
How many sessions would I need?
There is no established protocol, and we are not going to invent one. It is discussed after evaluation, as part of a broader plan.
Is it better than oral NAD+ precursors?
Most human research has actually used oral precursors like NR and NMN, which are far cheaper. IV delivery bypasses absorption, but that has not been shown to translate into better outcomes. For many people, starting oral is the more sensible first step, and we will say so.
Do you take insurance?
No. Venturis Clinic is direct-pay and does not bill insurance.
NAD+ therapy in Oklahoma City
Almost everyone who calls us about NAD+ is tired. Not ordinary tired — the kind that has lasted months or years, does not improve with sleep, and has usually been dismissed at least once.
The most useful thing we do is rarely the infusion. It is the part before it: working out what is actually causing the fatigue. Sometimes that is thyroid, or iron, or sleep apnoea, or a post-viral process, or mold exposure in a building, or Epstein-Barr reactivation. Those have specific answers, and an NAD+ drip is not any of them.
Where NAD+ does fit, it fits as one part of a broader plan — often alongside IV nutrient support, laser therapy, hyperbaric oxygen or ozone-based therapies, and always after the treatable causes have been looked for.
Dr. Alvin Philipose has practised in Oklahoma City for more than 25 years and works largely with people whose fatigue has not been explained elsewhere. The first conversation is a consultation, not a sales pitch.