EBOO Therapy in Oklahoma City

Extracorporeal blood oxygenation and ozonation, explained plainly, with the evidence and the screening steps.

Written by Dr. Alvin Philipose, DC, ICCP (Ret.) · Updated November 2026

EBOO therapy, short for extracorporeal blood oxygenation and ozonation, is the most intensive form of ozone therapy offered in a clinic. Venturis Clinic provides EBOO in Oklahoma City for patients from across Oklahoma, including Tulsa, Edmond and Norman, and for patients who travel in from Kansas, Texas and Arkansas. This guide covers what EBOO is, how a session works, who should not have it, side effects, how many sessions people usually do, and what the research does and does not show.

What is EBOO treatment?

EBOO treatment is a form of ozone therapy in which your blood is filtered outside the body, exposed to medical-grade oxygen and ozone, and returned in one continuous loop. At Venturis Clinic in Oklahoma City, it is offered only after a Good Faith Exam and is administered by our licensed nursing staff under our medical director.

EBOO stands for extracorporeal blood oxygenation and ozonation. “Extracorporeal” means outside the body. During a session, blood is drawn from one arm, passed through a sterile filter where it is exposed to a controlled mixture of medical-grade oxygen and ozone, and returned through the other arm in a continuous loop. The setup is closer to a dialysis-style circuit than to a standard IV drip.

EBOO grew out of earlier ozone techniques such as major autohemotherapy (MAH) and “10-pass” ozone. Its main difference is volume: because blood flows continuously through the filter for the whole session, more blood is exposed to the oxygen-ozone mixture than in a single IV ozone treatment.

How an EBOO session works, step by step

1. Check-in and vitals. Staff confirm how you are feeling, review any medication changes and take your vital signs.
2. Two IV lines. One line is placed in each arm: one to draw blood, one to return it.
3. The circuit. Blood passes through a sterile, single-use filter and tubing set while oxygen and ozone are introduced at protocol-set concentrations. An anticoagulant is used in the circuit per protocol to keep blood from clotting in the tubing.
4. Monitoring. Staff stay with you and monitor you throughout. Most people read, use their phone or rest.
5. Finish and post-check. The lines are removed, pressure is applied to both sites, and staff recheck your vitals before you leave.

Filters and tubing are single-use and sterile, and are never reused between patients. Most people go about their day afterward; some prefer to have someone drive them home after their first session.

EBOO vs. 10-pass vs. IV ozone

For a detailed side-by-side, read EBOO vs 10-Pass vs IV Ozone Therapy. For other ozone options, see ozone therapy in Oklahoma City.

Is EBOO safe? Screening and who should not have it

EBOO is a blood-handling procedure, so screening matters more than marketing. Before your first session, a licensed member of our medical staff, working under our medical director, completes a Good Faith Examination that reviews your history, medications and recent labs.

EBOO is not appropriate, or needs extra caution, if you have:

• G6PD deficiency. G6PD is an enzyme that protects red blood cells from oxidative stress. Without it, ozone can cause red blood cells to break down (hemolysis). We screen for it before anyone starts.
• Pregnancy. Ozone therapy is not used during pregnancy.
• Uncontrolled hyperthyroidism.
• Bleeding or clotting disorders, or blood thinners. Anticoagulant use requires coordination with your prescribing physician and may rule EBOO out.
• A recent heart attack, stroke or unstable heart condition.
• Severe anemia, very low blood pressure, or veins that cannot support two IV lines.
• Highly reactive mast cell activation. This requires careful evaluation first.

EBOO side effects

Common and usually short-lived:

• Tiredness or a “washed out” feeling for a day or two
• Bruising or soreness at the IV sites
• Mild headache, lightheadedness or muscle aches

Less common:

• A drop in blood pressure or a vasovagal (fainting) reaction during the session
• Reaction to the anticoagulant used in the circuit
• Clotting in the circuit, which ends the session early
• Rarely, infection at an IV site or hemolysis

Call the clinic for anything that worries you after a session, and call 911 for chest pain, trouble breathing or fainting.

What the research shows, by evidence level

EBOO has a small research base, and we think you should see it plainly before you decide anything.

• Controlled clinical trial (small): A 2005 trial randomized 28 people with peripheral artery disease to EBOO or an IV drug (prostacyclin). The EBOO group showed greater regression of skin lesions. It was one small study, from one research group, in one condition.^[1]
• Early case reports (no control group): The first report in people, from the same group in 2000, described EBOO in a small number of patients and reported no side effects. Without a control group, it cannot show whether EBOO caused any change.^[2]
• Proposed mechanism (lab and theory): Researchers describe a controlled, low-dose oxidative stress that may prompt the body’s own antioxidant responses. This is a hypothesis, not a proven clinical effect.^[3][4]
• Broader ozone research: A 2026 umbrella review of ozone therapy trials rated the certainty of the evidence low or very low for every outcome it looked at. EBOO was not among the uses it reviewed.^[5]

There are no large, well-controlled trials establishing EBOO as a treatment for any disease. EBOO is not FDA-approved to diagnose, treat, cure or prevent any disease. If a clinic tells you EBOO will detoxify you, remove heavy metals or resolve a named condition, it is describing something the evidence does not currently establish. If you are under a physician’s care for a condition, EBOO is something to discuss with that physician, not a replacement for their care. For more detail, read what the research says about EBOO benefits, and for what is known about safety, read EBOO side effects and safety.

How many EBOO sessions will I need?

There is no standard number, and anyone quoting one before evaluating you is guessing. As a general pattern:

• Initial series: often 3 to 6 sessions, spaced 1 to 2 weeks apart
• Longer series: some patients do 6 to 10 sessions
• Maintenance: when used, often one session every 4 to 8 weeks

Your plan is set individually after your exam and reviewed as you go. You can stop at any time.

How long do EBOO results last?

It varies from person to person, and there is no reliable research answer. Some people notice changes within a few sessions, others do not notice a difference. That is why we reassess after an initial series rather than committing anyone to an open-ended schedule.

Is EBOO right for you? Start with a free call.

Every situation is different, so the first step is a free 15-minute call with Dr. Philipose. You can ask questions, talk through your history, and find out what screening would involve. There is no obligation.

Book a free 15-minute call · Request a call

What to expect: before, during and after

Before: eat a normal meal and drink plenty of water the day before and the morning of your session. Bring your current medication and supplement list.

During: wear a short-sleeved or loose top. Expect two needle sticks, then about an hour of sitting. Tell staff right away if you feel lightheaded, nauseated or unwell.

After: keep the IV-site bandages on for a few hours, stay hydrated and take it easy for the rest of the day if you feel tired.

For a step-by-step walk-through, read about your first EBOO session.

How to choose an EBOO provider in Oklahoma

• Is there a medical exam, including G6PD screening, before the first session?
• Who places the IV lines and monitors the session, and what are their licenses?
• Is there physician oversight, and an emergency plan?
• Are filters and tubing single-use and sterile?
• Does the clinic explain EBOO’s FDA status and the limits of the evidence honestly?

EBOO therapy near me: Oklahoma City, Tulsa and the region

Venturis Clinic is located at 7917 N. May Ave., Suite B, Oklahoma City, OK 73120, in the Nichols Hills area of north Oklahoma City, with easy access from Edmond, Norman, Moore, Yukon, Mustang and Midwest City. Patients regularly drive in from Tulsa and from across Oklahoma, and some travel from Kansas, North Texas and Arkansas. If you are traveling, we can usually complete your exam by phone or telehealth first and plan your sessions to minimize trips. Tulsa-area patients can read about EBOO for Tulsa patients. Coming from farther away? See traveling to Oklahoma City for EBOO for how a multi-day visit is planned.

EBOO blood treatment: what happens to your blood

People often search for “EBOO blood treatment” because the idea of treating blood outside the body is new to them. During EBOO, only a small amount of blood is outside your body at any moment. It flows through sterile, single-use tubing into a filter where it meets a measured mix of medical oxygen and ozone, then returns through your other arm. Over about an hour, a large volume of blood passes through the circuit. Published work from the University Hospital of Siena described treating up to several liters of blood in about an hour of circulation (Di Paolo et al., 2005).

Conditions patients ask us about

Patients who ask about EBOO are often living with long-standing concerns. These are conversation starters, not promises; options are discussed after your Good Faith Exam:

• Long COVID and post-viral symptoms
• Mold-related illness (CIRS)
• Mast cell activation (MCAS)
• Autoimmune conditions
• MCAS symptoms: signs of mast cell activation
• Epstein-Barr virus (EBV) reactivation
• ME/CFS and chronic fatigue
• Lyme disease
• Chronic fatigue and other complex conditions
• Neuropathy and nerve symptoms with normal tests
• Dysautonomia
• POTS (postural orthostatic tachycardia syndrome)
• Mold toxicity symptoms

How our therapies fit together

EBOO is often one part of a broader plan. Depending on your exam, labs and goals, our clinical team may discuss pairing EBOO with IV nutrient therapy, UBI (ultraviolet blood irradiation), Weber intravenous laser or red light therapy. We plan combinations carefully and check in regularly so the plan keeps fitting you.

More EBOO resources

• What EBOO is and how blood ozonation works
• EBO2 vs EBOO: what’s the difference?
• EBOO therapy side effects and safety
• EBOO vs dialysis
• EBOO in Oklahoma vs. going to Mexico
• EBOO vs 10-pass vs IV ozone
• Download the free EBOO patient guide
• EBOO therapy benefits: what the research shows

Frequently asked questions about EBOO

What is EBOO therapy?

EBOO stands for extracorporeal blood oxygenation and ozonation. Blood is drawn from a vein, passed through a closed, sterile, single-use filter circuit where it is exposed to a controlled oxygen-ozone mixture, and returned through a second line.

How is EBOO different from IV ozone or 10-pass?

All three expose blood to medical ozone. EBOO uses a continuous circuit and filter with two IV lines, and processes a larger volume of blood per session than a single IV ozone treatment. Our EBOO vs 10-pass vs IV ozone page walks through the differences.

Is EBOO FDA-approved?

No. EBOO is not FDA-approved to diagnose, treat, cure or prevent any disease, and ozone is not an FDA-approved medical therapy in the United States.

What does the research actually show?

The EBOO-specific evidence is small: one small controlled trial in peripheral artery disease and earlier reports without a control group. Most other claims rest on proposed mechanisms. See the evidence section above.

Who should not have EBOO?

EBOO is not appropriate, or needs extra caution, for people with G6PD deficiency, pregnancy, uncontrolled hyperthyroidism, bleeding or clotting disorders or blood thinners, a recent heart attack, stroke or unstable heart condition, severe anemia or very low blood pressure, or highly reactive mast cell activation. Your eligibility is reviewed during your Good Faith Examination, including G6PD screening, before any session.

What are the possible side effects?

The most common are short-lived: tiredness, bruising or soreness at the IV sites, and mild headache or lightheadedness. Less common are a drop in blood pressure or fainting during the session, a reaction to the anticoagulant used in the circuit, and, rarely, infection at an IV site or hemolysis. See EBOO side effects and safety.

How long does a session take?

Session length varies. Typically it is about an hour on the circuit, plus time for check-in, IV placement and a short rest afterward.

Does EBOO hurt?

Most people feel two needle sticks for the IV lines and little else. Some feel cold or tired during the session.

Can I drive after EBOO?

Most people can. For your first session, consider having someone drive you in case you feel tired.

How many sessions do people have?

There is no standard, research-backed number. Any plan is set individually after your exam and reviewed as you go, and you can stop at any time.

Is EBOO the same as a “blood oil change”?

No. That phrase is a nickname. EBOO does not replace or clean your blood; it exposes a steady stream of it to oxygen and ozone and returns it to you.

Is EBOO basically dialysis?

No. The circuit looks similar: blood leaves one arm, passes through a filter and returns through the other. Dialysis removes waste and fluid for people whose kidneys are not working, while EBOO exposes the blood to oxygen and ozone. EBOO is not a substitute for dialysis. For a side-by-side comparison, see EBOO vs. dialysis.

Is EBOO covered by insurance?

No. EBOO is not covered by insurance, and Venturis Clinic does not bill insurance. Cost depends on the plan set after your exam and is discussed during your consultation.

How do I find out if EBOO is right for me?

Book a free 15-minute call with Dr. Philipose. We will talk through your history, what screening involves, and whether EBOO makes sense to explore.

Talk it through before you decide

Book a free 15-minute call with Dr. Philipose, request a call, or call (405) 848-7246. We will tell you honestly whether EBOO makes sense for you, and if it does not, we will say so.

References

1. Di Paolo N, Bocci V, Salvo DP, et al. Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease. Int J Artif Organs. 2005;28(10):1039-1050. doi:10.1177/039139880502801012
2. Di Paolo N, Bocci V, Garosi G, et al. Extracorporeal blood oxygenation and ozonation (EBOO) in man. Preliminary report. Int J Artif Organs. 2000;23(2):131-141. doi:10.1177/039139880002300212
3. Di Paolo N, Gaggiotti E, Galli F. Extracorporeal blood oxygenation and ozonation: clinical and biological implications of ozone therapy. Redox Rep. 2005;10(3):121-130. doi:10.1179/135100005X38888
4. Bocci VA, Zanardi I, Travagli V. Ozone acting on human blood yields a hormetic dose-response relationship. J Transl Med. 2011;9:66. doi:10.1186/1479-5876-9-66
5. Cacciatore S, Abbatecola G, Calvani R, Veronese N. Effectiveness and safety of ozone therapy in humans: an umbrella review of systematic reviews with meta-analyses of randomized clinical trials. Med Sci (Basel). 2026;14(2):289. doi:10.3390/medsci14020289

EBOO and ozone therapy are not approved by the U.S. Food and Drug Administration for the treatment of any disease. They are not guaranteed to diagnose, treat, cure or prevent any condition. Individual results vary. A Good Faith Examination by licensed medical staff is required before any session. This page is educational and is not medical advice.