What Is EBOO Therapy? How Blood Ozonation Works

By Venturis Clinic, Oklahoma City · Updated October 2026

EBOO therapy (extracorporeal blood oxygenation and ozonation) is a form of ozone therapy in which a small, steady stream of your blood is drawn from one arm, passed through a sterile filter that exposes it to a controlled mix of medical-grade oxygen and ozone, and returned through the other arm in a continuous loop. A session takes about an hour on the circuit. At Venturis Clinic in Oklahoma City, EBOO is performed by licensed medical staff under our medical director, and only after a Good Faith Exam.

This page explains how blood ozonation works in plain language: what happens to the blood, how EBOO differs from other ozone methods, who should not have it, and what a first visit looks like. For pricing, sessions and our full service details, see our main EBOO therapy in Oklahoma City page, and for costs and packages, our EBOO therapy cost guide.

What EBOO stands for

Each letter describes part of the process:

• Extracorporeal means “outside the body.” The blood is treated in a closed circuit next to you, then returned.
• Blood is what passes through the circuit, not a separate fluid.
• Oxygenation means oxygen is introduced to the blood in the filter.
• Ozonation means a measured concentration of ozone, a reactive form of oxygen made of three oxygen atoms, is introduced at the same time.

You may also see the terms “blood ozonation,” “EBO2” or “ozone dialysis.” “Ozone dialysis” is a nickname, not an accurate description: EBOO uses a filter that looks similar to a dialysis filter, but it does not do the job of a kidney and is not a replacement for dialysis.

How blood ozonation works

Ozone is unstable. When it meets blood, it reacts within seconds with fats and antioxidants in the plasma and on red blood cells. Those reactions produce short-lived messenger molecules. The theory behind all medical ozone therapy is that a small, controlled oxidative signal prompts the body’s own antioxidant and repair systems to respond. Researchers describe this as a hormesis effect: a mild, measured stress that triggers an adaptive response.

That theory comes mostly from laboratory and small clinical studies. It has not been confirmed in large controlled trials, and EBOO is not approved by the U.S. Food and Drug Administration for any medical condition. We explain this at every consult so you can decide with accurate expectations.

What makes EBOO different is how much blood passes the oxygen-ozone mixture. In a single standard IV ozone treatment, one bag of blood is drawn, ozonated and returned. In EBOO, blood flows continuously through the filter for the whole session, so a much larger volume is exposed over the hour.

EBOO compared with other ozone methods

• Standard IV ozone (major autohemotherapy, or MAH): one draw of blood, mixed with ozone, returned through the same line.
• 10-pass ozone: repeated cycles of draw, ozonate and return through one line, so more blood is treated in batches.
• EBOO: two IV lines and a continuous filter circuit, so the largest volume of blood is treated in one session.

More volume is not automatically better for every person. The right method depends on your veins, your history and your goals. Our side-by-side guide, EBOO vs 10-pass vs IV ozone, walks through the differences in detail.

What happens during an EBOO session

1. Check-in and vitals. Staff ask how you are feeling, review any medication changes and take your vital signs.
2. Two IV lines. One line is placed in each arm: one draws blood, the other returns it.
3. The circuit. Blood passes through a sterile, single-use filter and tubing set while oxygen and ozone are introduced at protocol-set concentrations. An anticoagulant is used in the circuit per protocol so blood does not clot in the tubing.
4. Monitoring. Staff stay with you throughout. Most people rest, read or use their phone for the roughly 60 minutes on the circuit.
5. Finish and post-check. The lines come out, pressure is applied to both sites, and your vitals are rechecked before you leave.

Plan on about 90 minutes in the clinic in total. Filters and tubing are single-use and sterile and are never reused between patients.

Who EBOO may suit, and who should not have it

People who ask us about EBOO are usually adults living with long-standing symptoms, such as fatigue after a viral illness or problems that began after mold exposure, who have already been through standard care and want to understand every option. Some want an ozone method that treats more blood than a single IV. Whether EBOO is reasonable for you is decided after a Good Faith Exam, not before.

EBOO is not appropriate, or needs extra caution, if you have:

• G6PD deficiency. Without this enzyme, ozone can cause red blood cells to break down. We screen for it before anyone starts.
• Pregnancy. Ozone therapy is not used during pregnancy.
• Uncontrolled hyperthyroidism.
• Bleeding or clotting disorders, or blood thinners, which need coordination with your prescribing physician and may rule EBOO out.
• A recent heart attack, stroke or unstable heart condition.
• Severe anemia, very low blood pressure, or veins that cannot support two IV lines.
• Highly reactive mast cell activation, which needs careful evaluation first.

Safety and side effects

EBOO is a blood-handling procedure, so screening and staff experience matter more than marketing. The most common effects are minor: bruising or soreness where the lines were placed, lightheadedness, and tiredness later that day. Less common risks include a drop in blood pressure, a vein that will not run well enough to finish the session, and reactions to the anticoagulant. In EBOO, ozone is not breathed in and is not injected as a gas; it is only introduced into blood inside the closed circuit.

Before your first session, our licensed medical staff review your history, medications and recent labs during the Good Faith Exam, and order any screening labs you still need, such as G6PD.

What a first visit looks like

Your first visit is a consult and Good Faith Exam, not a treatment. We go through your health history, what you have already tried and what you hope to get from EBOO, explain the evidence honestly, and answer questions. If EBOO is a reasonable option, we schedule it. If it is not, we tell you, and we may suggest a gentler starting point from our IV therapy menu or other ozone options.

Cost: EBOO is direct-pay. Cost is discussed at consult, and you get an exact price before you schedule.

What is EBOO therapy? Frequently asked questions

What does EBOO stand for?

Extracorporeal blood oxygenation and ozonation. Blood is oxygenated and ozonated outside the body in a sterile circuit, then returned.

Is EBOO the same as dialysis?

No. EBOO uses a similar-looking filter, but it does not clean the blood the way a kidney or dialysis machine does and is never a substitute for dialysis.

How long does an EBOO session take?

About 60 minutes on the circuit and roughly 90 minutes in the clinic, including check-in and the post-session check.

Is EBOO FDA-approved?

No. EBOO and ozone therapy are not FDA-approved for any medical condition. We make no outcome claims and discuss the evidence at consult.

Does EBOO hurt?

Most people feel the two needle placements and little else. Some feel tired or lightheaded afterward, and some prefer to have someone drive them home after the first session.

Do I need an exam first?

Yes. Every patient has a Good Faith Exam with our licensed medical staff, plus any needed screening labs, before a first EBOO session.

Venturis Clinic is at 7917 N. May Ave, Oklahoma City, OK 73120. We see patients from Oklahoma City and surrounding areas, including Tulsa, and patients who travel in from neighboring states.

EBOO and ozone therapy are not approved by the U.S. Food and Drug Administration for any medical condition. No specific result is promised, and individual results vary. A Good Faith Exam by licensed medical staff is required before any session. This page is educational and is not medical advice.