By Venturis Clinic, Oklahoma City · Updated October 2026
For most people who are properly screened, EBOO therapy is well tolerated, and the most common side effects are mild: tiredness on the day of treatment, lightheadedness, or bruising where the IV lines were placed. Like any procedure that involves IV access and a blood circuit, it also carries less common risks, which is why every patient at Venturis Clinic in Oklahoma City has a Good Faith Exam and screening labs before a first session.
Is EBOO treatment safe?
Safety with EBOO comes down to three things: choosing the right patients, using proper sterile equipment, and having trained staff monitor every session. In published work from the University Hospital of Siena, researchers reported more than 1,200 EBOO treatments in 82 patients and described the procedure as feasible without notable technical or clinical problems in their setting (Di Paolo et al., 2005). A small randomized trial from the same group recorded no side effects or complications across 210 EBOO sessions (Di Paolo et al., 2005).
Those reports are reassuring, and they are also small. We treat that as a reason to be careful, not a reason to skip steps. At Venturis, EBOO is performed by licensed medical staff under our medical director, using a sterile, single-use circuit.
Common, usually mild side effects
- Tiredness or a “washed out” feeling for the rest of the day. Some people feel more energetic instead. Both are common.
- Lightheadedness during or shortly after a session, especially if you came in hungry or under-hydrated.
- Bruising or tenderness at the IV sites, which usually fades within a few days.
- Feeling cold during the session as blood circulates through the circuit. We keep blankets on hand.
- Short-lived “detox-type” feelings such as mild headache or fatigue for a day. Let us know if anything lasts longer.
Less common risks
- Fainting (vasovagal reaction) during IV placement, particularly in people with a history of fainting around needles.
- IV site problems such as infiltration, irritation or, rarely, infection.
- Bleeding-related issues, because the circuit uses an anticoagulant to keep blood flowing. This is why we review blood thinners and bleeding history carefully.
- Red blood cell stress in people with G6PD deficiency, a genetic enzyme condition that makes red cells more vulnerable to oxidative stress. Screening for G6PD before ozone therapy is standard practice at our clinic.
Who should not have EBOO, or needs extra care
Please tell us right away if any of these apply. Some rule EBOO out; others simply mean we choose a different option or take extra precautions:
- Known G6PD deficiency, or unknown status (we can test for it)
- Pregnancy, or planning a pregnancy
- A bleeding or clotting disorder, low platelets, or current blood thinner use
- Uncontrolled overactive thyroid
- A recent heart attack or stroke, unstable heart rhythm, or very low blood pressure
- Seizure disorders that are not well controlled
- Very difficult veins, or a strong history of fainting with IVs
Screening labs before your first session
Before ozone-based therapy, our clinical team typically orders screening labs, decided at your Good Faith Exam. Common examples include:
- G6PD to check the enzyme that helps red blood cells handle oxidative stress
- Complete blood count (CBC), including hemoglobin and platelets
- Metabolic panel for kidney, liver and electrolyte basics
Additional tests may be ordered based on your history through our lab testing service.
How we keep sessions safe
- A full Good Faith Exam and medication review before any treatment
- Screening labs, including G6PD, before ozone therapy
- Sterile, single-use tubing and filter for every session
- Measured ozone dosing chosen by our clinical team
- Continuous staff monitoring of how you feel, your vitals and your IV sites
- Clear aftercare instructions and a direct line to our office
What to expect after a session
Most people return to normal activities the same day. Drink plenty of water, eat a good meal, and consider having someone drive you after your first session. Call us at (405) 848-7246 if you have questions, and seek urgent care for anything that feels severe.
Frequently asked questions
What are the side effects of EBOO therapy?
Most are mild and short-lived: tiredness, lightheadedness, feeling cold during the session, and bruising at the IV sites.
Is EBOO safe if I have G6PD deficiency?
G6PD deficiency is a key reason to avoid or modify ozone therapy. We screen for it before your first session.
Can I have EBOO if I take blood thinners?
Possibly not, or only with precautions. We review every medication at your Good Faith Exam.
Will I feel worse before I feel better?
Some people feel tired for a day after a session. Lasting or severe symptoms are not expected and should be reported to us.
How is EBOO different from IV ozone for safety?
Both use ozone and IV access. EBOO uses two IV lines, a filter circuit and an anticoagulant for about an hour, so screening and monitoring are especially important. See EBOO vs 10-pass vs IV ozone.
Learn more or talk with us
Read more about EBOO therapy in Oklahoma City, compare EBO2 vs EBOO, or download our free EBOO patient guide. When you’re ready, book a free 15-minute discovery call.
EBOO and other ozone therapies are not approved by the U.S. Food and Drug Administration to diagnose, treat, cure or prevent any disease. Individual experiences vary. All services are performed by licensed medical staff under our medical director after a Good Faith Exam. This page is educational and is not medical advice. If you have a medical emergency, call 911.