By Venturis Clinic, Oklahoma City · Updated October 2026
EBO2, EBO2O3, EBOO and “ozone dialysis” are different names for closely related ways of exposing blood to oxygen and ozone outside the body and returning it in a continuous loop. The names mostly reflect who built the equipment and how it is marketed, not a fundamentally different treatment. At Venturis Clinic in Oklahoma City we offer EBOO, performed by licensed medical staff under our medical director after a Good Faith Exam.
Why there are so many names
When people start researching blood ozonation, they quickly run into a confusing list of acronyms. Here is what each one generally refers to:
- EBOO stands for extracorporeal blood oxygenation and ozonation. It is the term used in the original published research from Italy, where the technique was developed and studied in the 1990s and 2000s.
- EBO2 stands for extracorporeal blood oxygenation. It is a name some clinics and device makers use for a similar oxygenation circuit, often with ozone included.
- EBO2O3 adds O3, the chemical symbol for ozone, to make it explicit that ozone is part of the gas mix.
- “Ozone dialysis” is an informal nickname. It comes from the fact that these systems use a dialysis-style filter, not because the treatment is dialysis. (We explain that difference on our EBOO vs dialysis page.)
Across all of these, the core idea is the same: a small, steady stream of blood leaves one arm, passes through a sterile, single-use filter where it meets a measured mix of medical oxygen and ozone, and returns through the other arm.
What actually differs between systems
Because the underlying idea is shared, the meaningful differences are practical ones. When comparing clinics or devices, these are the details worth asking about:
- The filter and circuit. Is it sterile and single-use? What type of gas-exchange filter is used?
- How ozone is dosed. How is the ozone concentration chosen, measured and adjusted for each person?
- Session length and blood flow. How long is the circuit run, and at what flow rate?
- Who is in the room. Who places the IV lines, who monitors you, and is a medical director overseeing care?
- Screening. Is there an exam and screening labs, such as G6PD and a complete blood count, before the first session?
Those questions matter far more than the acronym on the brochure.
EBOO and EBO2 compared with other ozone methods
Extracorporeal systems sit at one end of a range of blood-ozonation methods. For a fuller side-by-side, see EBOO vs 10-pass vs IV ozone. In brief:
- IV ozone (major autohemotherapy): a measured amount of blood is drawn, mixed with ozone and returned once.
- 10-pass: the draw-and-return cycle is repeated several times in a visit.
- EBOO / EBO2: blood circulates continuously through a filter for the length of the session, so a larger volume of blood is exposed over time. The published Italian work described treating up to several liters of blood in about an hour of circulation (Di Paolo et al., 2005).
What the published research describes
Most of the peer-reviewed literature on extracorporeal ozonation uses the term EBOO. Researchers at the University Hospital of Siena reported more than 1,200 treatments in 82 patients in a 2005 review and described the technique as technically feasible in their setting (Di Paolo et al., 2005). The same group published a small randomized trial in 28 patients with peripheral artery disease, reporting improvement in skin lesions compared with the comparison treatment and no complications recorded across 210 EBOO sessions (Di Paolo et al., 2005). Engineers have also described purpose-built gas-exchange filters for the procedure (Bocci et al., 2007).
This is an encouraging foundation, and it is also early. Studies are small, and EBOO, EBO2 and related therapies are not FDA-approved to treat any disease. That is why every plan at Venturis starts with an exam, labs and regular check-ins.
What we offer at Venturis Clinic
We offer EBOO therapy in Oklahoma City using a sterile, single-use circuit, with sessions run by our nursing team under our medical director. Many patients pair EBOO with IV nutrient therapy or light-based therapies as part of a broader plan. Whether EBOO is right for you, and how often, is decided together after your Good Faith Exam.
Frequently asked questions
Is EBO2 the same as EBOO?
They are closely related. Both describe circulating blood outside the body through a filter exposed to oxygen and, usually, ozone. The names differ mainly by device maker and marketing.
What does EBO2O3 mean?
It is EBO2 with “O3,” the symbol for ozone, added to show ozone is part of the gas mix.
Why is it called ozone dialysis?
Because the systems use a dialysis-style filter. It is a nickname; EBOO is not a kidney treatment.
Which one is better?
No head-to-head studies show one branded system is better than another. Safety screening, dosing, sterile equipment and the team running it matter most.
Can I get EBO2 or EBOO in Oklahoma?
Yes. Patients come to our Oklahoma City clinic at 7917 N. May Ave from across the metro, Tulsa and surrounding states.
Talk it through
Have questions about EBOO, EBO2 or which ozone method might fit you? Book a free 15-minute discovery call or call (405) 848-7246. You can also download our free EBOO patient guide.
EBOO, EBO2 and other ozone therapies are not approved by the U.S. Food and Drug Administration to diagnose, treat, cure or prevent any disease. Individual experiences vary. All services are performed by licensed medical staff under our medical director after a Good Faith Exam. This page is educational and is not medical advice.