Ozonated saline therapy is an IV drip of sterile saline that has had medical ozone bubbled through it just before use. It is a lower-intensity, slower form of ozone therapy than major autohemotherapy, and it is one of several ozone options our Oklahoma City team may discuss with you after an evaluation. It is not right for everyone, and the research on it is thinner than for other ozone routes.
For the full picture of every ozone method we offer, start with our ozone therapy in Oklahoma City page.
Ozone therapy, including ozonated saline, is investigational and is not approved by the U.S. Food and Drug Administration to treat, cure or prevent any disease. This page is general education, not medical advice. Individual results vary.
What ozonated saline is
Ozone (O₃) is a reactive form of oxygen. In ozonated saline therapy, an ozone-oxygen mixture made on site from medical-grade oxygen is passed through a bag of sterile saline for a set time. The saline is then given through an IV over a set period.
The idea behind it is the same as other ozone methods: a small, controlled oxidative signal may prompt the body to step up its own antioxidant and repair responses. Because ozone breaks down quickly in water, the amount that reaches the body this way is lower and harder to measure than when ozone is mixed directly with blood.
How it compares with other ozone methods
- Major autohemotherapy (ozone IV): blood is drawn, mixed with a measured ozone dose, and returned. It is the most studied systemic method and allows the most precise dosing.
- EBOO therapy: a continuous circuit that treats and filters a much larger volume of blood in one session.
- Ozonated saline: no blood is removed. It is a gentler, simpler drip, with less published research behind it.
Ozone experts disagree about how much ozone stays active in saline, and some major ozone societies do not include ozonated saline in their guidelines. We think you should know that before choosing it. For a side-by-side look at the systemic options, see EBOO vs 10-pass vs IV ozone.
Who may be a candidate
Ozonated saline is sometimes considered for people who:
- have difficult veins or do not want blood drawn and returned,
- want to start with a lower-intensity ozone option, or
- are pairing ozone with a vitamin IV infusion plan.
It is generally not given to people with G6PD deficiency, pregnancy, uncontrolled hyperthyroidism, low platelets or bleeding problems, or an unstable heart condition. See ozone therapy side effects and safety for the full list.
What a visit looks like
- Good Faith Exam. A licensed provider reviews your history, medications and goals.
- Labs, including G6PD screening before any systemic ozone. See lab testing at Venturis.
- Preparation. Saline is ozonated on site from medical-grade oxygen right before your infusion.
- The infusion. You relax in our infusion area while the drip runs, usually under an hour.
- Aftercare. Most people return to normal activities the same day.
Our ozone program was built by our founder, Alvin Philipose, who wrote the book Ozone Therapy: The Promising Science Behind Healing and Wellness and teaches ozone therapy to physicians. Infusions are performed by licensed medical staff under our medical director.
Side effects
Ozonated saline is usually well tolerated. People most often notice mild vein irritation, tiredness, or bruising at the IV site. Serious problems are rare when patients are screened and medical-grade equipment is used.
Cost
Cost depends on your plan and is discussed at your consultation. Venturis is direct-pay and does not bill insurance.
Frequently asked questions
Is ozonated saline the same as an ozone IV?
No. In a standard ozone IV (major autohemotherapy), your own blood is mixed with ozone and returned. Ozonated saline uses no blood; ozone is passed through saline that is then dripped in.
Is ozonated saline as strong as EBOO?
No. It is a much lower-intensity method. EBOO treats a large volume of blood in one session, while ozonated saline delivers a smaller, harder-to-measure amount of ozone.
How long does an ozonated saline session take?
Usually under an hour, plus time for check-in and monitoring.
How many sessions will I need?
There is no standard number. Any plan is set after your Good Faith Exam and adjusted based on how you respond.
Can ozonated saline be combined with vitamin IVs?
Sometimes, depending on the plan your provider recommends. Some combinations are scheduled on separate days.
Start with a conversation
Book a free 15-minute discovery call or call (405) 848-7246. Venturis Clinic, 7917 N. May Ave., Oklahoma City, OK 73120.